There is also the possibility several indirectly regulated proteins may be regulated at a tertiary level involving secondary regulators that control expression of additional tertiary transcription factors that subsequently affect cyst development (Fig. 4).
For example, mRNA levels in Drosophila [68] were found to be regulated at a post-transcriptional level without evident transcriptional regulation; however, simultaneous inhibition of both Erk and p38 kinase pathways decreased the levels of cytokine gene transcription (IL-6 and TNF-α) [69].
This can be partially explained by observations that the autophagosome marker ATG8 is rapidly up regulated under starvation conditions in yeast, and that most of the autophagy genes are regulated at a transcriptional level [ 62].
This manuscript provides an integrated transcriptomic view of small intestinal neuroendocrine tumors and identifies that these lesions are regulated at a developmental level, have key activation of hypoxic pathways (a known regulator of malignant stem cell phenotypes) as well as activation of genes involved in apoptosis and proliferation.
An integrated cellular transcriptomic analysis of small intestinal neuroendocrine tumors identified that they are regulated at a developmental level, have key activation of hypoxic pathways (a known regulator of malignant stem cell phenotypes) as well as activation of genes involved in apoptosis and proliferation.
The data show that planktonic bacteria seem to be regulated at a landscape scale controlled by land use, whereas biofilm bacteria are regulated at a biofilm matrix scale controlled by autochthonous production.
They also contribute to the understanding of how the nucleotide salvage pathway is regulated at a molecular level.
We used transcriptomic profiling to study the metabolic pathways since previous studies had shown that cellular metabolism was regulated at a transcriptional level [4, 6, 7].
In contrast, the beam power for the TEF-P is regulated at a level of several watts to ensure the safety of the subcritical assembly.
A novel video-controlled tensile testing method was utilized, which allows recording simultaneously axial strain, axial stress and volume strain while axial strain-rate is regulated at a constant value even after necking has begun.
