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Temsirolimus effectively inhibited the phosphorylation of S6 (P=0.02) and higher baseline levels of pS6 showed a trend towards being predictive of a better response (P=0.097).
Multivariate analyses identified high disease activity patients with both low complement levels and anti-dsDNA positivity, and those with SELENA SLEDAI scores of 10 or greater as being predictive of a response to belimumab treatment.
In the univariate analysis, prior HSCT, recipient CMV seropositivity and receipt of etoposide within the 6 months prior to HSCT were predictive or trended toward being predictive of a reduced risk of acute GVHD grade 2 or higher.
The impact of RAS mutations in KRAS exon 3 and 4 and NRAS exons 2, 3 and 4 appears to be similar to that of KRAS exon 2 mutations, with all mutations being predictive of a lack of response to panitumumab therapy.
Sämann [ 50] reported that increased left hippocampal gray matter volume was predictive of treatment response to a variety of antidepressant medications, and our meta-analysis supported the observation of reduced right hippocampal volume being predictive of a poorer clinical response [ 7].
People often have convictions that boil down to conditional assumptions of the type "If P, then Q," with a certain stimulus (P) being predictive of a particular outcome (Q), for example "If a dog barks, then he will bite" (see Hawton et al. 1989).
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But, Dr. Zipes said, in someone who has had a heart attack, "they may be predictive of a future life-threatening problem".
Strikingly, a higher miR-564 level is predictive of a significantly better distant relapse-free survival (DRFS) in breast cancer patients in GSE22220 dataset (Fig. 5G).
Lower baseline levels of xylitol was predictive of a greater decrease in BMI (β=0.06, P<0.01) and 10% weight loss (odds ratio (OR)=0.2, confidence interval (CI =0.07 0.7, P=0.01).
PET studies in healthy controls show that low D2 receptor binding is predictive of a pleasurable experience following the psychostimulant administration (Volkow et al, 1998).
Better baseline scores, later-onset epilepsies, fewer initial antiepileptic drugs, and seizure control were predictive of a better cognitive outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com