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After being on a stable dose and route of MTX for at least 3 months, 56.7% of the patients (59 out of 104) still had at least 1 active (i.e., swollen or tender) joint.
Detectable biologic drug levels correlated with a better clinical response in patients experiencing their first RA inadequate response while being on a stable biologic treatment with RTX, IFX, and ETN.
Detectable biologic drug levels correlated with a better clinical response in patients experiencing their first RA inadequate response while being on a stable biologic treatment with rituximab, infliximab, and etanercept (ETN).
The present study evaluated the concordance between serum drug and antidrug levels as well as the clinical response in RA patients treated with biological agents who experience their first disease exacerbation while being on a stable biologic treatment.
Since clinical response of biologic agents in RA can be influenced by their pharmacokinetics and immunogenicity, D. Mazilu and colleagues evaluated the concordance between serum drug and antidrug levels as well as the clinical response in RA patients treated with biological agents who experience their first disease exacerbation while being on a stable biologic treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com