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In 15 neonates, having only IgG antibodies in the serum was interpreted as being of maternal origin by the clinicians.
In 19 cases, the infant's IgG levels were interpreted by the pediatrician as being of maternal origin and were not followed.
In 8 case-patients, the IgG levels decreased in the neonates, and in 15 case-patients, IgG in the neonates' serum only was interpreted by the clinicians as being of maternal origin.
Abnormalities were determined as being of maternal origin in all dup(15) cases except for a 22-year-old female with undetermined origin of two extra copies of the 15q11.2-q13.1 region.
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Even more notably, by using DNA methylation-sensitive high-resolution melting-curve analysis of the SNRPN locus, which does not require DNA from the parents, we found that all eight duplications are of maternal origin, as in the original study.
All eight duplications at the AS/PWS region were of maternal origin (online supplement, section 5), thus supporting the original report.
The new functional SNV (p. Asp1113Asn) is of maternal origin, and also the novel intragenic deletion is maternally inherited.
The majority of extra chromosomes in trisomic offspring appears to be of maternal origin resulting from nondisjunction of homologous chromosomes during the first meiotic division.
Assuming that one member of each homologous pair was of maternal origin and the other was paternally derived, here was an event that fulfilled the behaviour of genes postulated in Mendel's first law.
However, abundant neutrophils have been found in the amniotic fluid of women with a severe acute maternal inflammatory response but without a severe fetal inflammatory response in the placenta, suggesting that these innate immune cells can also be of maternal origin or a mixture of both fetal and maternal neutrophils.
It is believed that the hormones, which are present in the oocytes and during the early embryonic stages in teleosts are of maternal origin (Greenblatt et al. 1989; Hwang et al. 1992).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com