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Although the full clinical impact of these new drugs remains undefined, emerging data suggest that the remarkable efficacy displayed in clinical trials particularly with raltegravir [13] is also being observed in routine care [14].
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Per protocol analyses risk overestimating the potential benefits that would be observed in routine practice.
No changes were observed in routine hematological parameters (results not shown).
This was observed in routine surveillance data collected from February 2001 to December 2005 in 21 medium-to-large public hospitals in Queensland, Australia [ 20].
Similar effects have also often been observed in routine analysis when grains are treated with chemicals such as fungicides.
Among those retained in care, glycemic control was achieved only in one-third of all patients and considerable shortcomings were observed in routine clinical and laboratory monitoring.
The presence of HPV in critically ill mechanically ventilated patients can be observed in routine clinical practice because these patients present with acute pulmonary hypertension if artificial ventilation is accidentally interrupted, and with severe hypoxaemia if drugs are administered that inhibit HPV [ 2].
Similar trends were observed in the routine care and the intensive treatment groups.
No serious adverse events were noted and, especially, no pathological findings could be observed in the routine blood tests.
No clinically relevant changes were observed in the routine serobiochemical variables analyzed after 12 months (Supplementary Table 1).
No participants were attending a first appointment, and doctors were not given a standard script but were observed in their routine practice.
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