Sentence examples for being localized to from inspiring English sources
From the observed staining patterns, we determined that when fractional mitochondrial or lysosomal mass accumulation was ≥40% there was an almost equal probability that the images were scored as being localized to (or not localized to) mitochondria or lysosomes, irrespective of the predicted percent accumulation (Figure 5A, B).
At least part of the functional specificity of SENPs appears to result in their subnuclear localization, with SENP3 being localized to the nucleolus and thereby de-SUMOylating nucleolar substrates, such as nucleophosmin [ 26], although recent results demonstrate that nucleolar SENPs, such as SENP3, can be released into the nucleoplasm following mild oxidative stress [ 23].
Subcellular localization of NOX4 is cell type dependent with NOX4 being localized to the mitochondria in cardiomyocytes, in the nucleus of endothelial cells, and at focal adhesions within vascular smooth muscle [42], [43], [44], [48], [49].
Therefore, it seemed possible that the bacteria were contained in digestive food vacuoles of the endosomal pathway, blocking amoebal digestion as opposed to being localized to the CV, as is the case for WT V. cholerae.
Interestingly, the G537R class 2 mutation (Kd = 348 nM; ka = 3.0 × 104 Ms−1; kd = 10 × 10−3 s−1) had a near identical effect on the kinetics of binding to VBC as did the F540L class 2 mutation (Kd = 345 nM; ka = 3.1 × 104 Ms−1; kd = 10 × 10−3 s−1), despite being localized to the kink region that does not make any significant contacts with pVHL.
As stated above, VMD2 was originally identified as being localized to RPE cells.
