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Expression of the scFvs provoked two types of effects: (i) inhibition of proliferation of all cell lines tested, this aspecific toxicity being likely due to the aggregation of unfolded scFvs; and (ii) apoptosis observed only in HPV16-positive cervical cancer cell lines after expression of 16E6-binding scFvs, this specific effect being proportional to the intracellular solubility of the scFvs.
Magnetic measurements show decreasing χT with decreasing temperature, for (Gd-38) this being likely due to antiferromagnetic interactions.
Using this protocol, Pink1 and park mutants showed degenerated myofibrils with a frequency of approximately 90% and 80% respectively as compared to controls (Fig 1N, O, R, S, V), the higher penetrance being likely due to the increased temperature.
Most of the Rx3-regulated eye field genes were only partially down-regulated, their residual expression being likely due to expression in domains outside of the eye field or partially reduced expression in the eye field due to redundant factors [ 12].
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