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The decreased expression of both Oct-3/4 and BMI-1 and the large shift in both phenotype and genotype is consistent with these genes being key regulators in the maintenance of stem cells (Niwa, 2001; Valk-Lingbeek et al, 2004).
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MCPIP1 acts as an RNAse regulating stability of some mRNA coding for proinflammatory cytokines and also regulates activity of transcription factors, which are key regulators in carcinogenesis (e.g., NF- κB) [ 18– 218.
Actually, peptides are considered the new generation of biologically active tools because they are key regulators in cellular and intercellular physiological responses, which possess enormous potential for the treatment of various diseases.
MiRNAs are key regulators in the miRNA-mediated regulatory networks.
Thus, miR156 and miR172 are key regulators in the juvenile adult phase change.
O-GlcNAcylation of the DELLA protein REPRESSOR OF ga1-3 (RGA) inhibits RGA binding to four of its interactors-PHYTOCHROME-INTERACTING FACTOR3 (PIF4), PIF4, JASMONATE-ZIM DOMAIN1, and BRASSINAZOLE-RESISTANT1 (BZR1 -that are key regulators in light, jasmonate, and BZR1 -thateroid signareng pathways, respectively.
The basic helix-loop-helix transcription factor Neurogenin2 (Ngn2) and NeuroD1 are key regulators in these processes.
Indeed, inflammation and inflammatory cells have been described to be key regulators in obesity and insulin resistance.
In the current transcriptomic study, we found high occurrence of WRKYs, which are key regulators in higher plants represent the top ten largest families of transcription factors and are found throughout the green plants [82].
In normal organisms, Id proteins are key regulators in development.
Heat shock transcription factors (Hsfs) are key regulators in heat shock response in eukaryotes and prokaryotes.
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