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The efficacy of uptake appears to be similar in all cell types we have examined with mitochondria being internalized in a time-dependent manner.
On the other hand, both functionalized systems proved capable of being internalized in a brain tumor cell line (i.e., glioblastoma A-172).
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We found that CysLT1 is internalized in a clathrin/Rab-5-dependent pathway; we also suggest that this internalization is arrestin-3-dependent.
So multiplication is a double terror: not only is it remote from our intuitive sense of number; it has to be internalized in a form that clashes with the evolved organization of our memory.
In this sense intuitionistic logic is "internalized" in a topos: intuitionistic logic is the logic of variable sets.
While different cell types may have a different composition of lipids and proteins in the plasma membrane, nanomaterials cross the plasma membrane and are internalized in a size-dependent manner via endocytosis pathways, such as clathrin-mediated endocytosis, caveolae-mediated endocytosis, or phagocytosis [45].
As expected m67 potently inhibited binding of IGF2 to cells expressing the IGF1R and its phosphorylation, and resulted in formation of multimolecular complexes when incubated with IGF2 and bound with high avidity to cells expressing FcγRII; the complexes were internalized in a macrophage-like cell line.
This suggests that the CysLT1R is internalized in a clathrin-dependent manner in both cell lines.
We examined primary rat adipocytes by subcellular fractionation to examine if the insulin receptor was internalized in a caveolae-mediated process.
Once bound to the plasma membrane, it has been shown that STx can be internalized in a clathrin- and caveolae-independent process [5] [8], and a recent study demonstrates that the lipids themselves contribute significantly to the earliest steps of toxin uptake into cells, that is, the formation of membrane invaginations [9].
Further, it is proposed that caveolae are internalized in a specific manner (Corrotte et al., 2013).
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