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As a positive control, we compared two X-chromosomal genes, one being inactivated (L1CAM, Figure 4A), the other being known to escape X-inactivation (UTX, Figure 4B).
An hypothesis which may account for the localization of the t(1 19) translocation breakpoint proximal to NOTCH2 may rely on a two-hit inactivation process with one allele of NOTCH2 being inactivated by the deletion and the remaining one by point mutation.
Against a background of low oxidative burden, increased CYP1A2 function may reflect the advantages of estrogen inactivation [ 17], with attendant increases in reactive oxygen species being inactivated by protective antioxidant systems.
Furthermore, Δ3 4-hiPS #6 and #37 skewed towards the same parental X-chromosome being inactivated, while Δ3 4-hiPS #20 skewed towards the alternative parental X-chromosome being inactivated.
In X-linked diseases, females may show a severe phenotype as a consequence of skewed X-chromosome inactivation, resulting in a higher percentage of the wild-type X-chromosome being inactivated in a specific tissue.
Macrophages, he said, are highly plastic and influenced by their environment, often being inactivated by the same tumors that they are attempting to fight.
Similar(27)
DNaseI was inactivated by vortexing (30″) and heat-inactivation (10', 65°C).
Instead, the reversion needs to be inactivated.
Duplicate e-mail addresses will be inactivated.
The virus in the vaccine is inactivated.
After the drug is gone, that memory should be inactivated".
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