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Although, the biological effect of the TP53 polymorphism polymorphism is currently unclear, theoretically, this polymorphism could affect mRNA splicing, altering the coding regions and therefore being implicated in regulation of gene expression and DNA-protein interactions, resulting in a defective protein [ 45, 46].
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In yeast, Ras small GTPases have been implicated in regulation of the cAMP pathway and suggested to regulate adenylate cyclase [ 66].
Extracellular-signal-regulated kinase (ERK -mediated signaling has bERK -mediatedd in regulation of signalingplasticity.
In particular, proteins that regulate mitochondrial dynamics, such as Mfn2 and Drp1 have been implicated in regulation of mitochondrial steps of apoptosis in mammalian cells.
MED14 has been implicated in regulation of lipid homeostasis.
Among the 11 rice CKXs, CKX2 has been implicated in regulation of rice grain yield.
Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways.
Trak1 is a ubiquitously expressed protein that has been implicated in regulation of mitochondrial transport (van Spronsen et al., 2013; Stowers et al., 2002; Brickley and Stephenson, 2011) and endosome-to-lysosome trafficking (Webber et al., 2008).
For instance, the PVN is implicated in regulation of sympathetically-mediated thermogenesis in brown adipose tissue [48], and the VMH is implicated in regulation of insulin secretion [49].
ERK pathway has been implicated in regulation of neuronal function, cell survival and in learning and memory [52].
We hypothesize that small RNAs may be implicated in regulation cascades by their ability to act on transposase gene expression.
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