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Rice-derived rhGCase displays all the molecular characteristics and pharmaceutical prerequisites for ERT of Gaucher disease, being highly equivalent to the native human enzyme.
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According to own unpublished data, acuity thresholds obtained by gratings or by two-point measurements are highly equivalent (Pearson-correlation, r = 0.716, p ≤ 0.001, n = 22 subjects), although thresholds obtained by gratings are slightly lower in general.
Foremost in the first category is the "small-world" effect: the observation that many biological and technological networks have a short mean path between nodes (as compared to an equivalent randomized network), while being highly clustered (again with respect to a randomized equivalent network [ 52], see also the review [ 53]).
Furthermore, the final 4,341 bp of the plasmid insert, not related to P1-rr, are highly similar to the equivalent p1-ww[4Co63] p1-ww[4Co63]3] sequences.
The other components supposedly deleted, afpF, atpE in ϵ-proteobacteria and α-proteobacteria are highly dissimilar to the equivalent E. coli genes, and are therefore not identifiable as homologs (e-value using BLAST > 0.01, data not shown; Figure 2b).
The nap mitotype carries only one copy of trnH, and the sequences of five of the six remaining genes are highly similar to their equivalents in the pol mitotype.
The polymerase and exonuclease domains are highly similar to their human equivalents.
Notice that, for large L the set-equivalent solutions are highly specific to the infererred H, e.g., for a given set of xor-genotypes it is very likely that any two different inferences H 1 and H 2 —which are not set-equivalent— can have very different set-equivalent solutions.
Readers do not want the drumbeat of war echoing from their newspaper or its online equivalent; in fact, they are highly sensitive to any hint of that, and want to see The Times be as skeptical and questioning as possible as the nation moves closer to military action.
In contrast, the FGFR1-equivalent substitution in FGFR3 (V555M) is highly likely to occur and was previously identified in the context of a cancer cell line (multiple myeloma KMS-11) dependent on an FGFR3 Y373C driver mutation (Chell et al., 2013).
However, at the higher Aae MutL concentrations in the presence of ATP the plasmid was highly degraded when compared to equivalent enzyme concentrations in the absence of ATP.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com