ChIP-seq data from the ENCODE project confirmed the validity of these bioinformatic predictions; we found CTCF, GATA1, and GATA2 to be highly-enriched at K562-unique Kaiso binding sites, and RUNX3 and PU.1 to be highly enriched at GM12878-unique Kaiso binding sites.
The H2A.Z histone variant is highly enriched at both inducible and constitutive DHS sites and is subject to exchange during hormone activation.
As reported, we found that all the Sir proteins are highly enriched at heterochromatin region rather than euchromatin region in wild-type cells, while sir3Δ completely abolishes the Sir proteins binding over the heterochromatin region.
Recent work showed that myosin II and cytosolic CKs are highly enriched at the apical adherens junction of polarized intestinal epithelial cells, and pharmacological inhibition of CK markedly disrupts apical junction assembly and barrier integrity.
As flowing through a tube served as a model of blood vessels, the magnetically loaded mesenchymal stem cells (MagMSCs) were highly enriched at the site distance from the magnetic pole.
Likewise, a recent study demonstrated that BRD-containing protein 4 (BRD4) is highly enriched at enhancers associated with genes involved in multiple profibrotic pathways, where BRD4 is co-localized with profibrotic transcription factors, including ETS1, SRF, SMAD3, and NF-κb/p65 (Fig. 3) [103].
In contrast, TbKIN13-2 is highly enriched at the tip of the trypanosome flagellum (arrows, Fig. 2A).
Unlike chick embryo filamin, Dictyostelium Filamin does not localise at the cleavage furrow but it is highly enriched at the polar region of dividing cells (Figure S1. E).
Heat shock factor (HSF), which is in the nucleus before activation, is highly enriched at the hsp 70 loci 5 minutes after heat shock [34].
