Proteins in a species that are highly connected to each other as well as to a highly connected group of proteins in another species through similarity links would be clustered together and identified as meta-clusters (Fig. 1).
In DawnRank, a gene will possess a higher impact score (that is, rank) if the gene is highly connected to differentially expressed downstream genes (directly and indirectly connected).
We live in a world where impressions matter, where appearance is highly connected to impressions.
Financial performance is highly connected to the level of integration and coordination across risk, control, and compliance functions.
Initially, on Facebook with the likes of Zynga's FarmVille, and then on mobile led by the ubiquitous Candy Crush Saga, it tends to mean casual games that are highly connected to social media sites.
We also hypothesized that some component members of gene families may contribute disproportionately to the significance of a GFIN because they are highly connected to interacting gene partners that are enriched for CNV defects in ASD.
Discrete evidence indicates that poverty is highly connected to poor-quality soils, drought-prone climates, high-altitude residence, and lack of access to markets, urban areas, and ports or coastal areas.
It would seem that putting the commercial view ahead of professionalism has given priority to profiteering, and turned media institutions into commercial enterprises that are highly connected to centres of power and influence, and at many times even woven into them, in pursuit of maximal profits even if at the expense of the profession's code of ethics.
Although it is true that trading on WTO rules will not trouble the aviation industry because there are no tariffs for aircraft and parts, the sector is highly connected to Europe and has worries instead about non-tariff barriers – such as border checks and complying with similar regulations.
Although assembly approaches, such as bioprinting and directed assembly of tissue building blocks, are powerful tools for mimicking cellular organization of native tissues, one should bear in mind that cells are highly connected to their microenvironment and their fate changes with the spatiotemporal release of growth factors from their microenvironment.
