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It is already widely accepted that future clinical development of Hsp90 inhibitors is likely to see these agents being exploited in combination therapy as opposed to their use in monotherapy.
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Specifically, physical-layer network coding (PLNC) encompasses a rich variety of signal processing and coding techniques and may be exploited in combination with multiple antennas, orthogonal frequency-division multiplexing (OFDM), channel coding, signal detection, and resource allocation.
The accelerator of each compute node is exploited in combination with multicore processors of that node in performing block-level linear algebra operations in the overall, distributed solver algorithm.
Successively, a central composite design was performed in microplate bioreactors using a BioLector®, in which variations of these impressive parameters, glucose, glutamic acid and tryptophan concentrations were selected for optimization of product-biomass yield (YP/X). Results were exploited in combination with a RSM.
Based on this study, we demonstrate that the existing MSA methods can be exploited in combination to improve alignment accuracy, although novel approaches will still be needed to fully explore the most difficult regions.
Fourthly, DH oil palms could be exploited in combination with transgenic techniques that are now available for this crop [ 24].
We initiated this study, therefore, to determine whether the potency and low toxicity of the hydroxamic acid derivative vorinostat could be exploited in combination with weekly doxorubicin.
This approach is particularly suitable for scientific domains that profit from large amounts of data that reside in the public domain and that have to be exploited in combination.
Techniques such as metabolic labelling with stable isotopes can be exploited in combination with genome-scale metabolite profiling to reveal the in vivo activity of whole pathways and enzymes [ 23– 25].
The latter can be exploited, in combination with the fermentative capacities of microorganisms in the conversion of lignocellulosic biomass to high yields of the renewable energy source bioethanol and other value-added products [ 8, 9].
ADAM17 inhibitors are tested pre-clinically for treatment of triple-negative breast cancers (McGowan et al, 2012) and could, thus, be exploited in combination with GRP-targeting drugs for 'nuclear CSPP positive' basal-like cancers.
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