The most advanced of these is the bivalent rLP2806 vaccine being developed by Pfizer, which has been through phase II and is currently being evaluated in phase III trials [ 39].
The agent is being evaluated in Phase II controlled clinical trials in metastatic breast cancer patients.
The estradiol metabolite, 2-methoxyestradiol (2MEO), is currently being evaluated in Phase II clinical trials for the treatment of solid tumours and is undergoing preclinical evaluation for inflammatory conditions.
Based on these data, the ability of enoximone to deliver safe and efficacious palliative treatment of advanced/ultra-advanced chronic heart failure is being evaluated in Phase III clinical trials.
Rifapentine 900-mg, once-weekly dosing appears to be safe and well tolerated and is being evaluated in Phase III efficacy trials of treatment of latent tuberculosis.
It is currently being evaluated in phase I clinical trials as the first nucleic acid-based aptamer for use in cancer treatment in humans.
Two direct factor Xa inhibitors are emerging from phase II trials (betrixaban and YM150) and three are being evaluated in phase III trials (apixaban, edoxaban, and rivaroxaban) for the prevention of stroke and systemic emboli in patients with atrial fibrillation.
AGT-181, which is a tetravalent (two antibody arms and two enzymes) fusion of an anti-INSR antibody and α-L-iduronidase (ALI) (Boado et al., 2012), is being evaluated in phase I clinical trials (NCT02371226) for the treatment of mucopolysaccharidosis I (MPS I; Hurler Syndrome).
It is currently being evaluated in phase II clinical trials.
This malaria vaccine is being evaluated in Phase 1 and 2 trials in children at this site.
For example, the indolicidin-derived peptide omiganan is currently being evaluated in Phase III clinical trials for treatment of catheter-related infections [36].
