A promising radioligand for imaging myocardial α1-ARs, [11C]GB67, is now being evaluated in human PET experiments.
The combined use of LAG3 antagonist antibodies with established anti-PD1 therapies is currently being evaluated in human clinical trials.
Recent studies show that alginates can be effective in treating obesity, and currently, various functional alginates are being evaluated in human clinical trials (Georg et al. 2012).
Estetrol (E4), a naturally occurring estrogen only produced by the human fetal liver, is being evaluated in human studies for potential use in contraception and menopausal care.
On a number of different fronts, MVA-based vaccines against HIV/AIDS [11], [12], [13], [14], [15], [16], malaria [17], [18], tuberculosis [19], [20], HPV-induced CIN [21], [22], and melanoma [23] are being evaluated in human clinical trials.
Moreover, ZFNs are being evaluated in human gene therapy clinical trials for treating AIDS [ 11, 17- 19].
In fact, targeted ablation of these latter structures appears to prevent the onset of paroxysmal atrial fibrillation in dogs, and such therapies are being evaluated in humans (20– 20).
Incorporation of the Δ30 mutation into an infectious cDNA clone of DEN-1 wild type virus at a site homologous to that in DEN-4 attenuated DEN-1 for rhesus monkeys and is currently being evaluated in humans [ 14].
Some have also been evaluated in human beings [ 13- 15].
The in vitro stability of the 68Ga-labelled peptides was evaluated in human and rat plasma.
