Three phenols, BPA, benzophenone-3, and triclosan, were each above the LOD in at least 75% of study participants and were evaluated as single compounds in our analysis.
Paclitaxel, gemcitabine and oxaliplatin have been evaluated as single agents, and the combinations paclitaxel and gemcitabine (Hinton et al, 2002), oxaliplatin and gemcitabine (Kollmannsberger et al, 2004), cisplatin and irinotecan (Miki et al, 2002) and cisplatin and epirubicin (Madani et al, 2003) as combinations.
Gemcitabine has also been evaluated as single-agent therapy in multiple trials in both the first-line and refractory/resistant setting in doses ranging from 800 to 1,200 mg/m2 weekly for 3 weeks on a 28-day cycle with RRs as varied as 14.5% to 37% and OS of 21 months in the first-line setting to RRs of 20%too 37.1% and OS of 11 months in a pretreated setting [ 52, 53].
Available experimental data of cyclically and tensile-deformed copper single crystals were evaluated as quantitatively as possible in the framework of the composite model.
In these ongoing trials, SAR3419 is being evaluated as a single agent in patients with relapsed/refractory DLBCL and acute lymphoblastic leukemia as well as in combination with rituximab in patients with relapsed/refractory DLBCL.
Holistic rubrics are useful when only one attribute is being evaluated, as they detail different levels of performance within a single attribute.
58 Pazopanib was evaluated as a single agent in STS in an EORTC phase II trial, and showed single-agent activity in STS, including leiomyosarcoma and synovial sarcomas, but not in adipocytic tumors.
In this sense the changes are connected and can be evaluated as a single and logically interrelated reform package.
