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We believe that these data will greatly impact the development and design of future therapies being engineered to target and eradicate this highly aggressive cancer cell population.
The vectors described in this study are being engineered to target a selection of tumour-related genes, and experiments are underway to investigate whether the effectiveness of oncolytic virus treatment can be improved in tumours moderately susceptible to HSV infection when these targets are silenced.
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These vectors are engineered to target mucosal epithelium, so are ideal for targeted delivery aimed at preventing respiratory diseases.
FHV protein A was engineered to target the endoplasmic reticulum (ER) via a heterologous tobacco etch virus ER-targeting domain, and was expressed in cis or in trans relative to the replicating FHV RNA1.
Viruses can be engineered to target specific bacteria.
Based on genetic screening to identify the specific drivers for individual patients, siRNA can be engineered to target them specifically.
There is promising work being done with antiviral-viruses – viruses that are engineered to target and destroy other viruses.
NPs can be engineered to target distinct cellular components representing multiple pathways of immunity.
Because DNA-binding factors are modular in design, they can be engineered to target specific genomic sequences and perform pre-programmed regulatory functions upon binding.
Particulate systems which can be engineered to target specifically certain cells or tissues are another promising alternative.
In this respect, zinc finger protein DNA-binding domains can be engineered to target virtually any gene.
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CEO of Professional Science Editing for Scientists @ prosciediting.com