Thyroid scintigraphy revealed an increased uptake of 99mTc in these lesions, which was consistent with toxic multinodular goiter, and she was diagnosed with CNC.
Several gene expression changes are consistent with toxic effects from exposure to dioxin-like contaminants.
There is also the question of formaldehyde-induced hematotoxicity (i.e., decreased blood counts) and the conclusion by Zhang et al. (2010) that this was consistent with toxic effects on the bone marrow (i.e., myelotoxicity).
Decreased growth following treatments with 0.01 and 0.1 mM MJ and SA is consistent with a toxic response to MJ and SA.
Removal of accumulated mutant polyQ proteins has been shown to ameliorate the disease phenotype in mouse [4] and drosophila models [5], which is consistent with a toxic gain-of-function disease mechanism [6].
These findings are consistent with the toxic effects of common pyrethroids on fish [ 20].
In addition to inhibiting their own degradation, they also blocked degradation of other CMA substrates; which is consistent with a toxic gain-of-function of these mutants.
The findings in this patient are consistent with chronic toxic encephalopathy and are differentiated from other dementing processes such as Alzheimer's disease, multi-infarct (vascular) dementia, and alcoholic dementia.
Renal dysfunction is an important feature of acetaminophen induced liver failure [ 22], and the renal histology in treated animals was consistent with a toxic injury rather than the distinctive pattern of frank outer medullary tubular necrosis encountered with ischaemia, i.e., critical hypotension.
The most commonly reported AEs were cough, increased aspartate aminotransferase, and nausea, all of which were mostly mild or moderate (grade 1 or 2), in addition to corneal events and thrombocytopenia, which are consistent with the known toxic effects of other MMAF-linked antibody drug conjugates8 and were found to be manageable.
