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The results of these studies have always been mixed with no consensus on specific dietary factor or nutrient being conclusively responsible for development of T1D [ 20].
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More recently, it was conclusively demonstrated that OATPs/Oatps are responsible for transporting MC-LR (Fischer et al. 2005, 2010; Komatsu et al. 2007; Lu et al. 2008; Meier-Abt et al. 2007).
Although the identity of the person or group who fired upon the plane has never been conclusively determined, Hutu extremists were originally thought to have been responsible; later there were allegations that FPR leaders were responsible.
However, the cells responsible for this phenomenon had not been conclusively identified.
It has recently been conclusively demonstrated that this insert is the sole determinant responsible for the reverse movement exhibited by myosin VI [106,107].
The concepts of gluco- and lipotoxicity remain hypotheses; the exact mechanisms responsible for impaired β-cell function have yet to be conclusively proved.
Allegations that the Kremlin is responsible for the damaging hack of Democratic National Committee emails may never be conclusively proven, but there is plenty of evidence suggesting that Donald Trump's presidential bid can count on at least some backing from Moscow.
In vitro apoptosis is responsible but a role for apoptosis in vivo has not been conclusively demonstrated [4].
The enzyme systems responsible for the reductive conversion of curcuminoids have not yet been conclusively identified.
Whether APM is similarly responsible for individual cases or outbreaks of respiratory disease has yet to be conclusively determined.
If B cells are conclusively shown to participate in the development of transplantation tolerance, it will be important to define the responsible mechanisms in order to design monitoring assays and immunosuppressive regimens that favor the development of tolerance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com