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Similarly we did not include studies that reported the cost-difference (or cost effectiveness difference) between alternative drug regimens whose efficacy was being compared in randomized controlled trials.
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Synchronous and sequential regimens have not been compared in randomized clinical trials, and such trials would be extraordinarily difficult to design.
Although local intra-arterial fibrinolysis (LIF) using recombinant tissue plasminogen activator (rtPA) is a promising treatment, outcomes have not been compared in randomized trials.
It seems as efficient as NBCA, although it has never been compared in randomized trials.
Although the two groups of agents have not been compared in randomized studies, attenuated androgens appear to be more effective.
Letrozole and anastrozole are currently being compared in a large randomized head-to-head trial in early breast cancer (ClinicalTrials.gov identifier NCT00248170) [ 120].
Two interventions designed to increase the likelihood of entry into long-term treatment upon discharge from hospital detoxification are compared in a randomized controlled trial.
Two procedures have been compared in two randomized cross-over consecutive periods of one day each (3 oral cares a day)—on 1 day, they received routine oral care (oral care (O) then tracheal suction (T)) and on the other day they received optimized oral care (subglottic suction (SG1) then O then SG2 then T).
Two tillage treatments (CT, conventional tillage; NT, no-tillage) and three rates of N fertilization (0; 75 kg N ha−1, applied at top-dressing; 150 kg N ha−1, applied at pre-sowing and at top-dressing at equal rate), with two types of fertilizers (ammonium-based mineral fertilizer and organic fertilizer with pig slurry), were compared in a randomized block design with three replications.
These were compared in a randomized trial (the Study of Tamoxifen and Raloxifene, or STAR, trial) [ 87].
Chemotherapy versus best supportive care (BSC) was compared in a randomized study including both CC and pancreatic carcinoma [ 7].
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