Sentence examples for being causal for the from inspiring English sources
Although telomerase activity and telomere length varied in HPC particularly from older donors, an age-dependent decline was not significant arguing against telomere exhaustion as being causal for the aging phenotype.
Therefore, these three variants were excluded as being causal for the described phenotype.
Our method is similar to the approach of Giambartolomei et al. (34) that calculates the posterior probability of the same SNP being causal for the gene expression and disease risk locus.
Variants in SLC39A4 could be excluded from being causal for the phenotype of the affected Fleckvieh animals, suggesting a different aetiological basis of the syndrome observed in the Fleckvieh calves.
As we upweight the likelihood of being causal for the actual causal SNP in this simulation, we expect that the methods accounting for the prior information will show a better performance.
In a Bayesian framework, the evidence for association at each variant is measured using a Bayes Factor, which, with certain assumptions, can be used to calculate the posterior probability for each variant of being causal for the association in that region (11, 12).
All but three of our 20 candidate genes were causal for the blue module, with an average causality score rank of 25.
It is possible to identify a single or a few variants that are causal for the phenotype of interest, and to identify genes acting in pathways previously unknown.
We identified the kanamycin resistance gene and the transcription factor encoding rhaR gene to be causal for the growth defect in P. putida.
Such an increase in headache has not been demonstrated for glatiramer acetate [21], underlining the theory that it is a specific effect of interferon beta which is causal for the increased headache frequency.
Despite many studies showed an association between migraine and patent foramen ovale, it is still not known whether its presence might be causal for the migraine pathogenesis and currently its closure cannot be recommended for migraine prevention.
