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Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure activity relationship (SAR) analysis through systematic modification of the 5-deazaflavin template.
At this stage, the local temperature (where terminal bead is located) is still far from being capable of activating the thermo-sensitive nociceptors [31].
It is also known to be able to trigger the EMT phenomenon as well as being capable of activating stromal cells, such as osteoblasts [ 48] and osteoclast [ 49].
By being capable of activating or repressing transcription of multiple target genes, they affect the metabolism, physiological balance and progression in cells and the responses of cells to the environment.
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Among them only S1-M1 was capable of activating the transcriptional activity of Grp78 and Grp94 promoters.
Both wild-type and kinase-dead IRAK1 are capable of activating NF- κB transcriptional activity (Maschera et al, 1999).
Short SDF1α-peptides derived from its receptor-activating domain are capable of activating the SDF1α specific receptor CXCR4.
It was recently reported that, although all class I PI3K family members are capable of activating Akt, only PI3Kγ is responsible for the activation of MEK/ERK [47].
The mixture of the oxidized polymers were capable of activating TLR2 and TLR1/2 transfectant only few folds above the range of activation observed with the pre-implant material.
ASC is capable of activating the wild type caspase-1 but not the cysteine active site mutant of caspase-1.
Dock-C members do not show unified GEF activity, i.e., Dock6 and Dock7 are capable of activating both Rac or Cdc42, whereas Dock8 preferentially activates Cdc42.
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