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To date, approximately 70 susceptibility genes have been identified as being associated with type 2 diabetes (T2D) at a genome-wide significant level (P < 5 × 10−8).
No such MAF gradient was observed in other European samples (ESM Fig. 3) We found no evidence of common SNPs in LARS2 being associated with type 2 diabetes in our samples.
So far a few genes, identified through linkage scans or the candidate gene approach, have been confirmed as being associated with type 2 diabetes e.g. PPARG, KCNJ11 and TCF7L2 [ 2– 4].
The downregulations of myostatin and IGF-IEa may underlie our previous report on satellite cells showing significantly more satellite cells being associated with type I and fewer with type II muscle fibres in subjects compared to those without trapezius myalgia [ 27].
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Furthermore, we examined whether the FTO locus is associated with type 2 diabetes independently of its association with BMI.
Circulating sex hormone levels are associated with type 2 diabetes, but the causal nature of these associations is controversial.
Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes.
"Most genes that have been associated with type 2 diabetes are related to the pancreas.
This polymorphism is exclusively found in Ameri-indian populations and is associated with type 2 diabetes.
To date, 68 loci have been associated with type 2 diabetes (T2D) or glucose homeostasis traits.
The fractures mostly originated from the calcaneus and were associated with Type I coalition with posterior hooking or Type III.
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