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Several other anticoagulant agents have been studied in medical patients or are currently being assessed in randomized controlled trials.
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Analgesics have traditionally been assessed in randomized clinical trials (RCTs) designed to demonstrate analgesic efficacy relative to placebo or an active comparator.
Some treatments have been assessed in randomized trials, but most such trials have been too small to detect treatment effects of a magnitude that would be realistic to achieve with a single intervention.
The effectiveness of RT has not been assessed in randomized trials that specifically examined patients with oligodendroglial tumors.
The duration of effectiveness of AIs and tamoxifen can be assessed in randomized trials of first-line therapy in advanced breast cancer.
The impact of 25-OH vitamin D supplementation on the infection rate and death of cirrhotic patients should be assessed in randomized trials.
Two drug regimens have been assessed in randomized clinical trials and cohort studies with different results because of negative drug interactions leading to unexpected toxicities or low efficacy in some cases.
32 The role of active surveillance has not been assessed in randomized trials, but it appears that almost all recurrences can be successfully treated with chemotherapy or radiotherapy making this a safe and desirable approach.
The impact of recent new treatment approaches; expanding transplant criteria and the availability of a systemic therapy with sorafenib on drop-out rate, recurrence and OS have to be assessed in randomized studies.
Surgery has during the latter decades been supplemented by intraperitoneal chemotherapy, most commonly in the form of hyperthermic intraperitoneal chemotherapy (HIPEC) using Mitomycin C. HIPEC has been implemented as standard therapy in many treatment centers, although its superiority to surgery alone has not been assessed in randomized controlled trials.
PEGPH20 is currently being assessed in a randomized Phase 2 clinical trial assessing its efficacy as a first-line therapy against metastatic pancreatic cancer in combination with gemcitabine/nab-paclitaxel compared to gemcitabine/nab-paclitaxel alone (https://clinicaltrials.gov/ct2/show/NCT01839487).gov/ct2/show/NCT01839487
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