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Interestingly, when WHO subtypes were simplified into three groups A-B22 vs B3 vs C), the survival curve showed more distinct pattern with type B3 being an intermediate prognostic group.
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45, 46 Trisomy 12 as the sole cytogenetic deviation is associated with a intermediate prognostic impact (median survival = 114 months) 47 but recent studies suggest that CLL patients with trisomy 12 and NOTCH1 (Notch homolog 1) mutations have a prognostic course worse than that with trisomy 12 alone.
Among AMLs with abnormal cytogenetics, the presence of t(8 21), t(15 17) or inv(16) is widely recognized as conferring favorable prognosis, while a variety of other chromosomal aberrations define a poor prognostic group.[1] However, the majority of AMLs are cytogenetically normal (CN) and collectively define an intermediate prognostic group.
This observation is consistent with the clinical observation that mutations of SF3B1 and 11q22-q23 deletion co-segregate with an intermediate prognostic group of CLL (Döhner et al., 2000; Oscier et al., 2013; Rossi et al., 2014).
There is an intermediate step.
They're an intermediate gender.
There might be an intermediate solution.
So it's an intermediate object.
Well this is an intermediate step.
That's an intermediate step.
Finance is an intermediate good like trucking.
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