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The fact that impaired cognition was rare can be explained by dementia/severe cognitive impairment being an exclusion criterion.
50 Remarkably, about 70% of patients enrolled in this trial had M1c stage (with pretreated central nervous system metastases not being an exclusion criteria), and 37% had elevated serum lactic dehydrogenase (LDH) levels.
Rimonabant use was associated with increased neurologic and psychiatric adverse effects including seizures, depression, anxiety, aggressiveness and suicidal thoughts despite depressive mood being an exclusion criteria for the clinical trials.
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Secondary MDS was an exclusion.
"It's an exclusion we made a judgment on," Ms. Antonelli said.
Use of estrogen within the previous 6 months is an exclusion factor.
In professional liability insurance there is an exclusion for any agreement guaranteeing the result of any treatment.
Therefore, low motivation should not necessarily be an exclusion criterion.
Smoking was an exclusion criterion in all studies.
Serum creatinine > or =1.5 mg/dl was an exclusion criterion for the SYMPHONY trials.
Change in medical treatment between the first and second study date was an exclusion criteria.
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