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For example, in Figure 5, save the model's ability to identify TEL-AML1 leukemias as being additionally coordinated, gate-keeper focused gene expression scatter plots are almost as revealing as model-predicted DNPS vs. DNTS scatter plots.
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Apparently this is not possible for steric reasons, and two OMc ligands coordinate only in an η manner; to occupy all the available coordination sites two neutral McOH ligands are additionally coordinated to the same Ti atom (Ti2).
The Cu atoms of these groups are additionally coordinated to the cyclo-P5 rings of 1 in a η-coordination mode, which is unique for this system.
When the second group was an amine or salicylaldimine moiety, these groups were additionally coordinated.
The Fe is additionally coordinated by two CN− and one CO.
The metal cation is additionally coordinated by two water molecules placed in axial positions of the octahedron.
12 The terminal Ti atoms Ti1 and Ti4 are additionally coordinated by four bridging OMc ligands, two of which connect Ti1 and Ti4 to the Ln atom and the other two to the central Ti atoms Ti2 and Ti3.
The orthophosphate forms a bridge not only from Mnα to Mnβ but also from Mnα to Mnγ and is additionally coordinated by the guanidinium group of Arg-194 projecting from the β6 α6 loop.
These four-membered rings are severely disordered over two (in 3) up to eight (in 4) positions around the direction of the chain and in some positions the Cu atoms are additionally coordinated by CH3CN, therefore, some of them show a trigonal, and some a tetrahedral environment (see the ESI ‡).
Three external ligands from a second KLK4 molecule (Glu74 Oɛ, Asp75 Oδ, and Gln76 Oɛ) are additionally coordinating the Zn2+ [137].
Importantly, the CFT tripeptide has been additionally proposed to help coordinate target recognition during enzyme interactions [ 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com