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When located at the apical plasma membrane, SMF-1 would then be largely inactive; being activated upon acidification of the endocytic vesicles by the vacuolar-ATPase [33], [48], [79].
Indeed, AMPK has been proposed as being activated upon H2O2 exposure, particularly through S-glutathionylation (fofmation of a mixed disulphide with GSH) of reactive cysteines located at the α- (Cys and Cys) and β-subunits (still not identified).
There is some literature on related effects of some genes being activated upon inhibition of CDK9 We thank the reviewers for pointing out the two papers, which have now been discussed in the revised manuscript.
There is some literature on related effects of some genes being activated upon inhibition of CDK9 Reviewer #1: This is a superb paper that should be published in eLife.
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As mentioned before, SRC is activated upon binding to activated ERBB2, whereas PI3K is activated by binding to activated ERBB3.
As mentioned before, SRC is activated upon binding to activated ERBB1 or ERBB2.
This promoter is active in HeLa as well A549 cells and is activated upon treatment of cells by TNFα.
All IP3R isoforms are activated upon cell stimulation, phospholipase C activation and subsequent IP3 production.
MALT1 paracaspase is activated upon antigen receptor stimulation to promote lymphocyte activation.
CyclinA/Cdk2 becomes active during S phase, and the CyclinB/Cdk1 complex is activated upon passing the G2/M checkpoint and inactivated upon entry into anaphase [22].
MAPKs are activated upon exposure to stress, leading to the phosphorylation and activation of p53.
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