The two-phase hydroformylation of lower olefins (Ruhrchemie Rhône/Poulenc process) is a well known example of a multiphase fluid fluid reaction (two liquid phases and a gas phase).
Karl Popper's conjectures and refutations model of the development of human knowledge is a well known example of a selectionist account which has been applied both to the ontogenetic growth of knowledge in individuals as well as the trans-generational (phylogenetic) evolution of scientific knowledge.
The various arms of the vertebrate immune response are interdependent, and the upregulation of one arm has extensive effects on the expression of other immune modes; the TH1/TH2 inhibitory dicotomy is a well known example of this effect.
Elevated steroid concentrations during developmentally sensitive periods can have organizational effects on the central nervous system and program certain facets of behavior; the effect of uterine androgen exposure on adult social phenotype of mice is a well known example [20].
Anthracyclines are a well known example of cardiotoxicity; the pathophysiological mechanism is complex but involves dose-related myocardial cell death during cancer treatment and possibly an impairment of reparatory and homoeostatic mechanisms after the exposure to chemotherapy [30,31].
Spiders, which are also Arachnidae, offer a well known example: the architecture and mechanical properties of different spider webs are correlated with the biological characteristics of their spinners, for example, aerial versus terrestrial capture habits.
It is a truism that the staying power of powerful and compelling ideas is better linked to their plausibility rather than to the actual evidence supporting them – a well known example being the miasmatic theory of infectious disease.
A well known example is the tropical vine genus Dalechampia, where resins are produced primarily for herbivore deterrence [ 35]; this trait was a preadaptation for the evolution of pollination systems based on resin reward [ 34, 36].
A well known example is the CDK inhibitor Sic1, which must be phosphorylated on at least six consensus CDK sites before Cdc4 can bind and target it for degradation [22].
A well known example is the PDE5 selective inhibitor sildenafil that has been used for the treatment of male erectile dysfunction and pulmonary hypertension [4], [10].
A well known example is the selection of hypermutator strains when bacterial populations are infected with phages or exposed to antibiotics [43], [44], [50].
