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T. cruzi takes up proline through two active transport systems, one of them being a high affinity, low capacity transporter called system A, and the other a low affinity high capacity transporter called system B [21].
This was distinct from the enzyme described by Monder, being a high affinity (low nM Km) exclusive 11β-dehydrogenase which used NAD rather than NADP(H) as co-substrate.
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TPR2A is a high affinity HSP90-binding domain, whereas TPR1 and TPR2B bind the HSP70 C-terminus with moderate affinity22,24.
Lehmann, J.M. et al. An anti-diabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ.
LNA is a high affinity nucleotide analog, nuclease resistant and elicits minimal toxicity.
It has been reported that ovarian cancer G protein-coupled receptor 1 (OGR1) is a high affinity receptor for SPC, and its closely related homologue GPR4 is a high affinity receptor for SPC with low affinity for lysophosphatidylcholine (LPC).
Calspermin is a high affinity Ca2+/calmodulin binding protein that is found only in postmeiotic male germ cells.
Grb10 was first found to be a high affinity interacting protein with IR in vitro (Liu and Roth, 1995).
Vorapaxar - a synthetic analogue of himbacine, is a high affinity and highly selective PAR-1 antagonist that can effectively inhibit thrombin-induced platelet aggregation.
We were able to claim that the generated molecule was a high affinity molecule because it appeared as such in the testing set.
Xenon is a high affinity antagonist at the NMDA receptor glycine site.
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