Sentence examples for being a downstream target from inspiring English sources

Cofilin phosphorylation was increased by CXCL12 or by nocodazole (Figure 5C), correlating with the increases in RhoA activity, and was reduced by an inhibitor of ROCK1 and ROCK2, Y-27632 [45], consistent with cofilin being a downstream target of ROCK [46].

Several lines of evidence indicate that PIAS1 senses environmental ROS by being a downstream target of JNK signaling.

To test this, we quantified Drs mRNA levels from infected OreR flies, with Drs being a downstream target of Toll signalling (Lemaitre and Hoffmann, 2007).

This raises the hypothesis that the low level of PUMA could be due to alternative mechanisms (other than simply being a downstream target of p53).

Remarkably, in almost all the double-injected embryos (87%, n > 200), the progeny of the blastomere that received exogenous hbox12 mRNA firmly detained GFP staining within the cytoplasm, consistent with p38 being a downstream target of Hbox12.

These animals have a less severe phenotype than the pat-9 RNAi animals that have embryo lethality and larval arrest, but are still consistent with TBX-2 being a downstream target of PAT-9 [ 29, 30].

4E-binding protein 1 (4EBP1) is a downstream target of mTOR.

We wondered whether Ezh2 is a downstream target of JNK in regulating Bim expression.

Our findings show that Ezh2 is a downstream target of P38α/JNK pathways, establishing a connection between critical P38α/JNK signals and PRC2, an essential epigenetic regulator.

The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.

For example, the multi-drug exporter channel protein ABCB1 was identified to be a downstream target of β-catenin in CML54.