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Being a downstream factor of mTOR, p70S6K is directly and only regulated by mTORC1.
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Therefore, PhaPR1 could be a downstream factor in the PhaNPR1-mediated defense pathway.
Although we did not provide direct evidence to show that EAF1 is a downstream factor of non-canonical Wnt4 signaling, the possibility exists that this is the case based on the conserved structure and function between EAF1 and EAF2/U19.
At the same time, EAF2/U19 is a downstream factor in the non-canonical Wnt 4 signaling pathway required for eye development in Xenopus laevis, and along with EAF1, contributes to convergence and extension movements in zebrafish embryos through Wnt maintenance.
IGF2 is a downstream factor of IGF2BPs, especially IGF2BP2.
PI3K is a downstream factor of IRS-1 and controls the phosphorylation of Akt.
We also showed that the AKT pathway was a downstream factor of SBSN.
Smad3 is a downstream factor of TGF- β/Activin/Nodal signaling.
NF-κB, which is a downstream factor of LOX-1, is a pivotal transcription factor involved in atherosclerosis.
A recent report has indicated that VEGF-C, the primary mediator of lymphangiogenesis, is a downstream factor regulated by SIRT1 [ 25].
Akt has been shown to be a downstream factor of SphK1, promoting cell proliferation and survival in several cancers such as leukemia, glioblastoma, and prostate cancer.
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