Sentence examples for being a downstream effector from inspiring English sources

The difference in the degree of macropinocytosis elevation was consistent with Rabankyrin-5 being a downstream effector of Rab5 that is directly involved in macropinocytosis [34]; elevating Rab5 levels would promote the activation of an existing endogenous pool of Rabankyrin-5, whelevatingvating Rabankyrin-5 would have a direct and more pronounced effect on macropinocytosis.

It also closely resembles the phenotype of IGF-receptor null mice [84], prompting the conclusion that despite being a downstream effector of multiple growth factor receptors, PKBα/Akt1 and PKBβ/Akt2 are the most critical effectors of IGF signalling during development [41].

These data are consistent with Rho kinase being a downstream effector of the PCP signalling pathway in lung development.

As phenotypically both Notch and RhoC signalling molecules regulate similar features during tumour progression, we explore the possibility of RhoC being a downstream effector of Notch1.

Besides being a downstream effector gene containing a VDRE, CYP24A1 is an important component of the 1,25D calcium metabolism pathway.

The above results taken together suggest that PRR5L is a downstream effector of mTORC2.

Caspase 3 is a downstream effector caspase important in death receptor apoptotic mechanisms.

In particular, CEBPB is a downstream effector of the LH signaling pathway in granulosa cells [8].

PAK1 activation is very crucial in cell migration and is a downstream effector of CXCR2 signaling pathway [35].

These observations suggest that WOX1 is a downstream effector of C1q-mediated apoptosis, without involvement of complement activation.

Because our data indicate that enz acts cell autonomously, enz would be predicted to be a downstream effector if it acts in such a hormonal signaling pathway.