CREB is presumed to be a direct downstream target of activated ERK [17].
The gene PIK3CA, which encodes the PI3K catalytic subunit, has previously been demonstrated to be a direct downstream target of transcription factor FOXO3a in CML [23], [24].
However, Dkk4 is a direct downstream target of Wnt [19], [20], [23], so that Dkk4 is not solely regulated by Eda.
Taking into consideration that SOC1 is a direct downstream target of CO [32], this observation also supports the notion that LOV1 acts upstream of CO and may act downstream or independently with GI.
Taken together, these results suggest that ABCA3 is a direct downstream target gene of SALL4, and the expressions of two ABC genes, ABCA3 and ABCG2, are positively regulated by SALL4.
Together with the in vivo data, these results support the concept that cyclin D1 is a direct downstream target of Sox17 in respiratory epithelial cells of CCSPrtTA/tetO-Sox17 mice.
Moreover, we demonstrate that Cby is a direct downstream target for the master ciliogenesis transcription factor Foxj1. Collectively, our results demonstrate that Cby facilitates proper postnatal lung development and function.
Furthermore, as Dll1 is a direct downstream target of Tbx6 in the paraxial mesoderm [40], [41], our observation that Dll1 is down regulated around the node at E7.5 in an area coincident with Tbx6 expression indicates that Tbx6 has a direct effect on Dll1 expression and suggests one possible mechanism for the disruption of L/R determination in Tbx6 null mutants.
Since cyclin D1 is a key regulator of progression through the G1 phase of the cell cycle and was increased in lungs from CCSPrtTA/tetO-Sox17 mice, we sought to determine if it was a direct downstream target of Sox17 during induction of respiratory epithelial cell proliferation.
HNF4G has a 3′-UTR binding site with miR-34a and is a direct downstream target of miR-34a.
