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In addition to being a difficult problem theoretically bucketing is essentially clustering the method we choose for bucket creation and assignment must be practically fast to handle the large number of reads we observe in most datasets.
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"That's a difficult problem".
It's a difficult problem.
We agree this is a difficult problem.
It is a difficult problem to solve.
"It's a difficult problem," he said.
How to do it is a difficult problem.
Reinvigorating democratic political competition is a difficult problem.
For patients, it can be a difficult problem to navigate.
However, measurement of their motions is a difficult problem.
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