Polymerization of the soluble β-amyloid peptide into highly ordered fibrils is hypothesized to be a causative event in the development of Alzheimer's disease.
I think a natural disaster, a natural property disaster, could be a causative event that could turn the market".
These results imply that a high level of SMEZ production by group A streptococcus is a causative event in the onset and subsequent severity of STSS.
An unanswered question is whether unrestricted cellular proliferation is a causative event in cyst initiation in ADPKD or it is restricted to a specific period during cyst expansion and growth.
These findings suggest that the dysfunction of the p53 could be a causative event leading to the autophagy, and that p53-DRAM signaling might be a key target for drug development and anti-autophagy therapy.
The discovery that inflammatory cytokine TNFα impairs insulin signaling greatly stimulated the field and scientists started to view that inflammation may be a causative event for the pathogenesis of obesity-related insulin resistance.
The detection of UPR-induced signals in these samples does not prove that ER stress was a causative event in the disease process; however, it does provide the first evidence that UPR markers are elevated specifically in the islets of diabetic men and mice.
The current challenge is to understand the underlying biologic mechanisms of these loci and how they confer risk for obesity; indeed, almost all of the SNPs capturing association in a GWAS outcome are not causal, rather they are tagging a causative event in the proximity of the signal so those key events have still also to be elucidated.
Increased β-catenin signalling (as a result of APC mutation) is a common causative event in colorectal cancer, and it is conceivable that DC switching could contribute to β-catenin dysregulation and so play a contributory role in the initiation of the early stages of colorectal tumorigenesis.
Recent studies suggest that silencing of the hMLH1 gene by promoter hypermethylation is a major causative event in the development of human gastric cancers with MSI (Fleisher et al, 1999, 2001; Kang et al, 1999; Leung et al, 1999; Suzuki et al, 1999).
Recent studies have suggested that silencing of the MLH1 gene by promoter hypermethylation is a major causative event in the development of human gastric cancers with MSI (Fleisher et al, 1999, 2001; Kang et al, 1999; Leung et al, 1999; Suzuki et al, 1999).
