Sentence examples for behind this downregulation from inspiring English sources
Interestingly, LRP1 is downregulated with age and in AD, and, although the mechanisms behind this downregulation remain unclear [ 35], research in mouse brains demonstrates that the presence of the ApoE 4ϵ allele blocks LRP1-mediated clearance of Aβ from the brain parenchyma [ 38].
The mechanism behind this downregulation remains unclear.
This downregulation was correlated with SMAR1 upregulation (Figure S3A).
Currently, the physiological implications of this downregulation are unknown.
Several potential mechanisms of this downregulation exist.
This downregulation is independent of SIV infection.
The reason for this downregulation is unclear.
Thus, other mechanisms may be behind the downregulation of miR-205 in the WPE1-NB26 cells.
The underlying mechanisms behind the downregulation of HER2 that could induce upregulation of MHC class I are currently unknown.
In addition, mutations or deletions of the miR-31 gene may also be key reasons behind the downregulation of the miRNA in prostate cancer.
