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Given such wide diversity of observations, we have therefore aimed to characterise the full spectrum of behaviours of wild type and resistant virus that might be observed within a flexible model framework.
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This trait ought to be retained by immortal hNSCs, if they are to provide a suitable, physiological model to mimic the behaviour of wild type hNSCs, while providing technical and practical advantages, such as long term and faster expandability in the absence of concomitant transformation.
The aim is to provide a simple to use software tool focused on the straightforward application of several state-of-the-art flux analysis methods and the simulation of the behaviour of wild type or mutant strains.
This confirms that GCN4 translational regulation is essentially captured by the simplified Model 2, and that Factor X is not required to explain the translational behaviour of wild type GCN4 mRNA.
It also allows the use of data sets that compare the behaviours of wild-type and mutant cells.
Before using the mutant protein in vivo, we checked whether its behaviour during an in vitro phosphorylation assay would corresponded to that of wild type DegS which had been phosphorylated by YbdM (as shown in figure 2).
The behaviour of wild-type and Oa1-deficient melanocytes also suggested that myosin Va was similarly recruited to melanosomes in both cell types.
Towards this end, we compare the behaviour of wild-type cells to the response of two mutants, as shown in Figure 4.
As shown in Fig. 4A, we found a significant influence of rilmenidine treatment on the behaviour of wild-type mice in this test.
This fluorescent TEM-1 V216C mutant with wild-type activity can mimic the catalytic behaviour of wild-type TEM-1, thus allowing itself to serve as an in vitro drug screening tool.
Duplex and R-loop substrates containing PAM 5′-CCC were not bound by N153A appreciably better than substrates −PAM in EMSAs, contrasting with the binding behaviour of wild-type Cas8′.
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CEO of Professional Science Editing for Scientists @ prosciediting.com