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The purpose of this study was to examine the anatomical and behavioural sequelae in the normal brain associated with tactile stimulation treatment during development.
Our initial indications that a significant number of children experience behavioural sequelae in the short to medium-term post Kawasaki disease was confirmed by more detailed investigation.
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As might be predicted from above, lesions involving the ACC have been linked with a wide range of cognitive, affective, and behavioural sequelae in both animals and humans.
11 43 Preeclampsia was also identified as an independent risk factor and has been associated with long-term cognitive and behavioural sequelae in general population samples, 44 46 and it has been suggested that adverse behavioural outcomes in late preterm infants may be associated with maternal hypertensive disease.
However, this approach is potentially confounded in that any behavioural sequelae may be the result of indirect effects of the lesion procedure on other brain areas, rather than as a direct consequence of cell loss in the target region.
Finding a significant correlation between Kawasaki disease and behavioural sequelae would provide the basis for an important added dimension in the long-term management of the disease.
It is these behavioural sequelae that we are interested in as we have documented many cases in clinic of reported behavioural problems persisting for months and years after the initial episode of Kawasaki disease.
In conclusion, we have shown significant behavioural sequelae can occur following acute Kawasaki disease.
Children with burn injuries, of the type included in this study, did not appear to develop significant psychological or behavioural sequelae.
Furthermore, anticonvulsant treatment can minimise cognitive and behavioural sequelae, and may have effects on future employment and recreation.
Additionally, further research in this area is required to rule out other possible causes of behavioural sequelae.
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CEO of Professional Science Editing for Scientists @ prosciediting.com