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In addition, availability of ASL in preclinical MRI should facilitate translational research; ASL studies might potentially illustrate new insights in ongoing pain in preclinical cohorts in which examination of simple behavioural endpoints in response to evoked pain has predominated to date [63].
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Behavioural change in response to disease is well recognized as an adaptive mechanism.
To understand root behavioural strategies in response to neighbours, we observed root growth for 20 species.
The items describe cognitive and behavioural efforts in response to stress.
However, recording of behavioural endpoints can be highly subjective and many animals may be required in order to see statistically significant change.
This was a relatively large study in a region with an expanding syphilis epidemic, using biomarker and behavioural endpoints.
Surrogate endpoints are generally easier to measure and standardize and save time compared with most behavioural endpoints.
Thus we sought to discover whether 2B3-201 would be more effective than free steroid at improving the MRI, behavioural and histological endpoints in the SOD1 G93A model of ALS.
To distinguish between brain responses reflecting the impact of vs. coping with emotional distraction, brain-behavioural correlations were calculated between activity in response to the transient anxiety-inducing emotional distraction and the behavioural measures.
These difficulties produce early physical and behavioural negative responses in the baby.
Secondary endpoints included Response Evaluation Criteria in Solid Tumors (RECIST -defined tumoRECIST -definedpharmacodynamic measures of tumort engagement.
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