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In the non-clinical comparison group, no behavioural changes were reported at the six-month follow-up assessment.
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Indeed, behavioural changes are reported prior to the onset of other clinical signs in both goats [ 13] and mice [ 14].
Behavioural changes were first reported by animal care staff at 314 dpi.
Behavioural changes were almost systematically mentioned.
Overall, behavioural changes were more significant among women.
These behavioural changes are similar to reports of severe dystonia in children with MSUD during acute decompensation (Crome et al., 1961; Silberman et al., 1961; Morton et al., 2002; Jan et al., 2003) and may represent an animal model of opisthotonus.
The offspring were then allowed to litter normally and develop until P60, a time at which behavioural changes have been reported after prenatal infection or the administration of infection-mimetic agents (Fatemi et al., 2005; Zuckerman & Weiner, 2005; Meyer & Feldon, 2010).
These levels of self-reported benefit and behavioural change were somewhat lower than those reported in previous studies using smartphone messaging apps [ 48, 62– 62].
This treatment regime is similar to that used in previous studies where beneficial changes to neuropathology and behavioural signs were reported [ 13- 15].
These behavioural changes are collectively referred to as 'sickness behaviour'.
Behavioural changes are usually attributed to predominant involvement of the right frontal lobe (Fig. 6).
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