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Paradoxically, mice exposed to both variables often exhibited a mitigation of abnormal behaviours, rather than increased behavioural abnormalities as expected.
Other behavioural abnormalities observed in our cohort are anxious personality, compulsive behaviour, aggressive behaviour and temper tantrums.
Four children displayed behavioural abnormalities, which consisted of autism, hyperactive behaviour, feeding disorder with language delay and axial hypotony with psychomotor delay.
SIRT3-myc corrected behavioural abnormalities, as well as changes in striatal dopamine turnover.
Disruption of PPI is considered a valid pharmacological model of some aspects of the behavioural abnormalities in schizophrenia.
These findings support the hypothesis of an involvement of dopaminergic system in behavioural abnormalities or psychosis occurring in ageing.
Huntington's disease is a genetic disorder characterised by progressive striatal and cortical neurodegeneration, resulting in a broad range of motor, cognitive and behavioural abnormalities.
These effects were apparent, even when SIRT3-myc was transduced after the induction of parkinsonism, at a time point when cell stress and behavioural abnormalities are already observed.
More global behavioural abnormalities may be noted, such as an increase in arousal and movement (described as psychomotor agitation or hyperactivity) which might reflect mania or delirium.
Lethargy, emaciation or behavioural abnormalities were reported in 26.9% (7/26) of these cases.
The resultant mice were homozygous viable and showed no obvious morphological or behavioural abnormalities.
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