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To analyze the dynamic behaviour of the complexes, extensive molecular dynamics simulations were carried out in explicit water.
The release behaviour of the complexes, as well as of their mixtures, was examined in simulated gastric (pH 1.2) and intestinal (pH 6.8) fluids.
The binding capability of these cationic polymers to the siRNA molecule, subsequently controls the surface/adsorption behaviour of the complexes to a negatively charged surface.
For compounds 2 and 3 there is a reasonable correlation between the behaviour of the complexes at high pressure and low temperature both crystallographically and spectroscopically.
Each system was firstly analysed by means of three runs of 20 ns molecular dynamics in order to better sample the conformational behaviour of the complexes.
The comparison between the drug release behaviour of the complexes and the relevant physical mixtures indicates that diltiazem gave rise to a less soluble and more stable complex with carrageenan than metoprolol.
Similar(54)
The model predicted correctly the dynamic behaviour of the complex organic system under transient conditions.
The luminescent behaviour of the complex and the ligand were also investigated and the complex shows blue shifted emission.
The chemistry of the liposomes (milk or soy) and the encapsulated bioactive structure can affect the viscoelastic behaviour of the complex itself.
Modelling tools were applied to describe the phase behaviour of the complex saline systems under different process conditions and were experimentally validated.
The thermal behaviour of the complex was studied by simultaneous thermogravimetry and differential thermal analysis being quite different from that of PVK.
More suggestions(18)
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behaviour of the concentrations
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behaviour of the cells
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