In fact, the expression/correlation behaviour of a large pathway could be misleading, hiding significant parts of the pathway mostly involved in the biological process under exam.
The model was simulated with the parameter values presented in table 2 and was able to describe the oscillatory behaviour of the pathway with a frequency of roughly 2h, in accordance to experimental observations [14].
The model was simulated with the parameter values presented in Table 1 and was able to describe the oscillatory behaviour of the pathway with a frequency of roughly 2.4 h, which is slightly higher that the reported approximately 2 h period in fibroblasts [14].
Subsequently we studied how a variation in the significant parameters would affect the behaviour of the pathway when varied one-at-a-time and in pairs of two.
The time-dependent behaviour of the pathway is described in the form of a narrative of events involving these basic entities and functions, which imposes a temporal sequence and defines inter-dependencies and contingencies.
The model developed herein incorporates all major components of the Notch signalling pathway, as described below, in an effort to study the behaviour of the delta/notch pathway in a single cell in the presence or absence of a delta signal from a neighbouring cell.
Herein, we have introduced a mathematical formulation that involves all the significant elements participating in the pathway, facilitating a more holistic description of the dynamic behaviour of the pathway.
We divide the intensities, separately for the group of single- and the group of multi-membership genes, per experiment by their sum, to obtain a measure of the contribution of each gene to the behaviour of the pathway.
The two most important features that have engaged the attention of theoreticians and experimentalists in this area are-a) the role of stochasticity in regulating the precision in the output of such pathways, and b) the effect of regulatory designs in conferring different dynamical behaviour of the pathway constituents.
To elucidate the behaviour of ethylene pathway components in capsicum during ripening, further analysis is therefore needed.
