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We determined binding of Natalizumab and its effects on the frequency, transmigratory behaviour and suppressive function of Tregs.
We here prospectively studied how Natalizumab binds to Tregs and delineated the effect on frequency, migratory behaviour and suppressive function of Foxp3+ T regulatory cells and their non-regulatory counterparts.
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Liu, W. et al. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ TReg cells.
Liu, T., Soong, L., Liu, G., König, R. & Chopra, A. K. CD44 expression positively correlates with FOXP3 expression and suppressive function of CD4+ TReg cells.
One key question is whether CD4+Treg are required for the generation and suppressive function of CD8+Ts.
After the expansion, the phenotype and suppressive function were assessed and cells were cryopreserved until needed.
We further show that TLR2 is dispensable for the development and suppressive function of CD4+CD25+Foxp3+ Treg in vivo.
To investigate the number and suppressive function of peripheral Tregs in patients with PLE compared with healthy controls.
We found that the number and suppressive function of regulatory T cells (Tregs) are crucial in the pathogenesis of PLE.
Thus, the oncogenic and suppressive functions of Nkx2-1 in the same tumour type substantiate its role as a dual function lineage factor.
Treg constitutively expressed CTLA-4 [ 8] and suppressive functions of some Treg subsets are dependent on CTLA-4 [ 10, 31].
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