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Scientists have been monitoring Tian Tian and signs that she was nearing mating season included grumpy behaviour and loss of appetite.
The milder sickness behaviour and loss of poly I C-induced I C-inducedAR1−/− animals suggested a role for IFN-inIFNAR1−/expression.
egl-10 encodes a conserved regulator of G protein signalling (RGS) protein involved in egg-laying and locomotion behaviour, and loss of its function causes defective egg-laying and sluggish movement [ 13].
At the same time, many changes in animals were found to occur in stressed animals irrespectively of the presence of hedonic deficit: hyperlocomotion observed in brightly illuminated open field, hypoactivity in the dark open field, increased scores of anxiety-like behaviour in the dark/light and elevated O-maze tests, high scores of aggressive behaviour and loss of body weight (Table 2).
The prodrome of PD and dementia with Lewy bodies, which is characterised by neuropathological changes that precede parkinsonism and dementia, includes rapid eye movement (REM) sleep behaviour disorder, a parasomnia with dream-enacting behaviour, and loss of REM sleep atonia [ 13,14].
Similarly, although all studies associate the presence of a BRAF V600E mutation with papillary architecture, several studies have reported a higher prevalence of BRAF mutations in tumours classified as tall cell or columnar cell variants of PTC that are associated with more aggressive clinical behaviour and loss of responsiveness to radioiodine (Nikiforova et al, 2003; Begum et al, 2004).
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In previous studies, we and others have noted that aberrant subcellular localisation of key proteins including those involved in DNA damage response (DDR) is associated with aggressive behaviour and loss-of-function phenotype (Wilson et al, 1999; Lambie et al, 2003; Rakha et al, 2008; Alshareeda et al, 2012, 2013, 2014).
Therefore, these results suggest that reestablishment of TGF- β signalling in T βRII null cells by stable expression of T βRII can reverse malignant behaviour of cells and loss of T βRII expression may be involved in lung tumour progression.
Many p53 target genes have been reported to be important for maintenance of normal cellular behaviour, and a loss of p53 regulation may cause abnormal expression of these genes.
When developmental problems go undetected and untreated, there is an increased probability of school failure, behaviour problems, low self esteem and loss of potential [ 6, 7].
Unemployment makes youth vulnerable to an array of risks and threats, ranging from poverty to risky behaviour, and from loss of self-esteem to, in certain instances, recourse to extreme violence.
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