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Two rounds of behavioral testing were conducted for all animals.
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A one and a half day workshop on behavioral testing was conducted in order to discuss experimental procedures and practices that may help enhance the utility of behavioral data as a reliable index of neurotoxicity and in the safety evaluation of chemical substances.
Behavioral testing was conducted following chelation therapy, from 2 to 9 months of age; this report presents the results of two of the administered tasks: (1) a conditional olfactory discrimination task (baseline task), and (2) a conditional olfactory discrimination task with periodic reward omission on some correct trials (RO task).
Behavioral testing was conducted during the dark phase of the light-dark cycle.
To avoid acute effects, all behavioral testing was conducted at least 3 hours after injections.
All behavioral testing was conducted at least 6 h after daily treatment.
Behavioral testing was conducted between 9.30 and 14.00 h, during the dark phase of the circadian cycle.
All the behavioral testing was conducted by the same experimenter in an isolated room and at the same time of the day.
Behavioral testing was conducted during the dark phase.
All behavioral testing was conducted during the day between 9 00 am and 12 00 pm.
Behavioral testing was conducted in 12 automated Plexiglas chambers, each operated by a personal computer.
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