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We developed a set of behavioral tasks designed to model components of these core symptoms in mice.
In animal experiments, the increase in ACh release, detected in brain areas during behavioral tasks designed to tax attentional processes, demonstrates that an activation of cholinergic neurons underlies arousal and attention.
Low-income children (n = 218, mean age 56.6 (range: 38.1 78.5; SD 7.0) months, 49.1% male, 56.4% white, 16.1% black, 11.5% Hispanic/Latino) participated in a series of behavioral tasks designed to elicit stress.
All animals were assessed on their abilities to perform several behavioral tasks designed to test locomotor and forelimb movement abilities prior to 6-OHDA injection and at 3 and 6 weeks post-injection.
To investigate the contribution of these genes to cognitive symptoms observed in DM1 patients, we studied the effect of deletion of Six5, Dmpk and Mbnl1 on three separate behavioral tasks designed to test learning and memory, anxiety and motivation.
More to the point, we examined spatial and temporal processing deficits in CGG KI mice using behavioral tasks designed to test specific hypotheses about the cognitive strengths and weaknesses reported in Fragile X Premutation carriers without FXTAS.
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Sixteen male subjects, eight CSB patients and eight non-patient controls, completed psychometric measures of impulsivity and compulsive sexual behavior, performed a behavioral task designed to assess impulse control (Go–No Go task), and underwent diffusion tensor imaging (DTI) procedures.
Freezing during all phases of cued-contextual fear conditioning, a behavioral task designed to study hippocampal-dependent associative learning, was enhanced.
The Maryland Resource for the Behavioral Utilization of the Reinforcement of Negative Stimuli (MRBURNS) is a novel behavioral task designed to measure individual differences in negative reinforcement-based risk taking propensity.
Using a pair of behavioral tasks designed specifically to evaluate resolution of spatial processing in CGG KI mice, it was demonstrated that CGG KI mice show deficits in processing the specific distances that separate two objects in space using a metric change detection task (also called a coordinate change).
Behavioral measures in tasks designed to assess cognitive processes in rodents characterize and dissociate these multiple influences.
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